A method for the synthesis of pyridines from aldehydes, alkynes and NH4OAc involving Rh-catalyzed hydroacylation and N-annulation.
نویسندگان
چکیده
A new method for regiocontrolled pyridine synthesis has been developed involving sequential Rh(I)-catalyzed chelation-assisted hydroacylation of alkynes with aldehydes followed by Rh(III)-promoted N-annulation of the resulting α,β-enones with another alkyne and NH(3).
منابع مشابه
Pyridine synthesis by reactions of allyl amines and alkynes proceeding through a Cu(OAc)2 oxidation and Rh(III)-catalyzed N-annulation sequence.
A new methodology has been developed for the synthesis of pyridines from allyl amines and alkynes, which involves sequential Cu(II)-promoted dehydrogenation of the allylamine and Rh(III)-catalyzed N-annulation of the resulting α,β-unsaturated imine and alkyne.
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عنوان ژورنال:
- Chemical communications
دوره 48 96 شماره
صفحات -
تاریخ انتشار 2012